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Over 95% of people develop antibodies due to Sinopharm, highly effective against Delta variant

20 Jul 2021

Research conducted by the Allergy, Immunology and Cell Biology Unit, Department of Immunology Molecular and Molecular Medicine of the Sri Jayewardenepura University has concluded that over 95% individuals in Sri Lanka developed antibodies against the Sinopharm vaccine. The study which investigated immune responses to the Sinopharm vaccine also found that antibody levels of those inoculated with the same were similar to levels seen following natural COVID-19 illness. It was also found very effective for the Delta variant as well as the Department noted that antibody responses to delta variant and neutralizing antibodies, were similar to levels seen following natural infection. The research team included Prof. Neelika Malavige and Dr. Chandima Jeewandara. Further, researchers from University of Oxford including Prof. Graham Ogg and Prof. Alain Townsend also participated in the study. It was also noted that the funding for this study was provided by the World Health Organization, UK Medical Research Council and the Foreign and Commonwealth Office and the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China. The summary of the findings are as follows:  “95% of individuals seroconverted following two doses of the Sinopharm/BBIBP-CorV vaccine. 20 to 39 years old had very high seroconversion rates (98.9%), although the seroconversion rates in individuals >60 years of age (93.3%) were lower. The vaccine induced neutralizing antibodies in 81.25% of vaccine recipients and these neutralizing antibody levels were similar to levels seen following natural infection. The antibody levels to delta and beta, were similar to levels following natural infection although the antibody levels were lower for alpha. The vaccine recipients only had a 1.38-fold reduction in antibody titers to delta compared to the Wuhan variant, compared to a 10-fold reduction to beta. The vaccine also induced T cell and memory B cell responses. The full preprint highlighting the results are available here: Antibody and T cell responses to Sinopharm/BBIBP-CorV in naive and previously infected individuals in Sri Lanka | medRxiv,” the University stated.

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