Air pollution has been linked to a swathe of lung cancer-driving deoxyribonucleic acid (DNA) mutations, in a study of people diagnosed with the disease despite never having smoked tobacco.
The findings from an investigation into cancer patients around the world helps explain why those who have never smoked make up a rising proportion of people developing the cancer, a trend the researchers called an “urgent and growing global problem”.
A senior author on the study at the University of California in San Diego, United States (US), Prof. Ludmil Alexandrov said that researchers had observed the “problematic trend”.
“Our research shows that air pollution is strongly associated with the same types of DNA mutations that we typically associate with smoking,” he said.
The scientists analysed the entire genetic code of lung tumours removed from 871 never-smokers in Europe, North America, Africa and Asia as part of the Sherlock-Lung study. They found that the higher the levels of air pollution in a region, the more cancer-driving and cancer-promoting mutations were present in the residents’ tumours.
Fine-particulate air pollution was in particular linked to mutations in the tumour protein 53 gene. These have previously been associated with tobacco smoking.
People exposed to greater air pollution also had shorter telomeres, protective strands of DNA found at the ends of chromosomes, which are often compared with the caps on shoelaces. Premature shortening of telomeres is a sign of more rapid cell division, a hallmark of cancer.
“This is an urgent and growing global problem,” said an epidemiologist on the study at the US National Cancer Institute in Maryland, Dr. Maria Teresa Landi.
With smoking in decline in many parts of the world, people who have never smoked are making up a larger proportion of lung cancer patients. Current estimates suggest that 10-25% of lung cancers are now diagnosed in this group. Almost all such cancers are a form known as adenocarcinoma.
Lung cancer remains the leading cause of cancer-related death worldwide. About 2.5 million new cases are diagnosed globally each year. Smoking, air pollution and other environmental contaminants are factors.
Recent research found that the highest rates of adenocarcinoma attributable to air pollution were in East Asia.
The latest work, published in Nature, identified only a slight rise in cancer-causing mutations in people exposed to secondhand tobacco smoke.
But, the study highlighted a significant risk from certain Chinese herbal medicines that contain aristolochic acid. Signature mutations linked to the herbal medicines were seen almost exclusively in never-smokers from Taiwan.
Another mysterious mutational signature was seen in people who had never smoked but not those who did, Landi said.
(The Guardian)